CLEAN ROOM EQUIPMENT

Vaporized Hydrogen Peroxide Pass Box

Highlights

Introduction

Features

Working Principle

Accessories

FAQs

Related Blogs

Highlights

Introduction

Features

Working Principle

Models

Door Configuration

Accessories

FAQ

Related Blogs

Introduction

Introducing our Static Pass Box – the ideal solution for controlled access and contamination prevention. Our Static Pass Box offers seamless material transfer while adhering to the highest cleanliness standards. With advanced features and robust construction, it ensures a hygienic environment for critical operations. Equipped with an interlocking mechanism and HEPA filters, our Pass Box prevents cross-contamination and delivers superior air purification. Safety features like door open alarms and a reliable fire suppression system provide added protection. Discover the efficiency and reliability of our customizable Static Pass Box for your specific industry needs.

Brinda Pharma Technologies is a leading manufacturer & exporter of quality clean room air showers for various applications in the following areas:

Pharmaceutical
Bio-Technology
Laboratory
Micro-Electronics
Aerospace

API Manufacturing
Excipient Manufacturing
Food Manufacturing
Advance Indoor Agriculture

A Vaporized Hydrogen Peroxide (VHP) Pass Box is an advanced contamination control equipment used in cleanroom environments to safely transfer materials between areas of different cleanliness levels without compromising sterility, utilizing vaporized hydrogen peroxide as a powerful sterilizing agent to eliminate bacteria, viruses, and other microorganisms before they enter critical zones; Brinda Pharma Technologies Pvt Ltd specializes in designing and manufacturing high-quality cleanroom equipment, including VHP Pass Boxes, tailored to meet industry standards, ensuring efficiency, reliability, and compliance with global GMP guidelines, especially for pharmaceutical applications where maintaining aseptic conditions and preventing cross-contamination is essential.
Brinda Pharma Technologies is a leading manufacturer and exporter of Vaporized Hydrogen Peroxide Pass Box – VHP for various applications in the following areas:

Pharmaceutical
Biotechnology and Life Sciences
Healthcare and Hospitals
Food & Beverage
Electronics & Semiconductor
Research Laboratories

These systems are especially valuable in Grade A & B cleanroom areas, helping maintain regulatory compliance and operational safety.

Features

High Cleanliness Standards: Designed to surpass even the strictest cleanliness standards, our Pass Box creates a sterile environment, essential for safeguarding sensitive operations.
Robust Construction: Carefully selected components and raw materials help achieve a strong constrution of the Dynamic Pass Box to ensure long-lasting performance and reliability without any interuption.
Advanced Interlocking Mechanism: Our Static Pass Box features an secure interlocking mechanism that permits the opening of only one door at a time with door opening delay time guaranteeing stringent containment and effectively preventing cross-contamination.
Easy Operation: Seamlessly navigate the Pass Box's intuitive control panel, facilitating easy operation, reducing downtime, and optimizing overall efficiency.
UV Disinfection: Take contamination control to new heights with UV lamps, providing an additional layer of powerful disinfection, eradicating harmful microorganisms. UV lamp burning hour display is also provided to monitor the efficiency of it as well as for regulatory purposes
Low Maintenance Advantage: Experience the convenience of minimal maintenance needs, allowing you to focus on your core operations while minimizing downtime.
Compliance with Industry Standards: Our Static Pass Box exceeds industry standards for Material Movement. We do also provide all the documents and protocols to ensure our client is consistently meeting the GMP & Regulatory Compliance requirements.

Features

Automation: Fully integrated VHP generation system with controlled injection, dwell, and aeration phases for repeatable and reliable sterilization cycles.
Sterilization Control: Precise regulation of VHP concentration (ppm), temperature, humidity, and exposure time to ensure effective bio-decontamination.
Advanced Precision: PLC-based automation with user-friendly HMI, multi-recipe management, data logging, and optional 21 CFR Part 11 compliance for audit trails and electronic records.
Real-Time Monitoring: Closed-loop system continuously monitors critical parameters like chamber pressure, VHP concentration, temperature, and humidity for process consistency.
HEPA Filtration: High-efficiency particulate air (HEPA) filtration ensures ISO-class cleanroom conditions inside the chamber during operation.
Uniform Vapor Distribution: Engineered airflow pattern eliminates dead zones, ensuring uniform sterilization across all surfaces and materials.
Airtight Construction: Robust chamber design with proven sealing integrity through pressure hold and helium leak testing to prevent contamination ingress or leakage.
Enhanced Safety: Interlocked double-door system with electromagnetic locking prevents cross-contamination and ensures operator safety during operation.
Efficient Aeration: Built-in catalytic converter rapidly breaks down residual hydrogen peroxide into water vapor and oxygen, reducing cycle time and ensuring safe handling.
Durable Build Quality: Constructed from SS 316L with electropolished internal surfaces (Ra ≤ 0.8 µm) for corrosion resistance, easy cleaning, and GMP compliance.
Sealing Options: Available with inflatable gaskets or mechanical sealing systems for superior airtightness and long-term reliability.
Smart Connectivity: Integrated data logging with SCADA/BMS connectivity enables centralized monitoring, remote diagnostics, and compliance reporting.
Regulatory Compliance: Designed in accordance with GMP, FDA, and international cleanroom standards, with full support for IQ, OQ, and PQ validation protocols.
Energy & Process Efficiency: Optimized cycle design reduces chemical consumption, energy usage, and overall operational cost while maintaining high sterility assurance levels (SAL).

Working Principle

A VHP Pass Box works by using vaporized hydrogen peroxide to decontaminate materials before transfer into cleanroom areas. Items are placed inside a sealed chamber, where VHP is injected and uniformly distributed to eliminate microorganisms. After the sterilization (dwell phase), the system removes residual vapor through aeration, converting it into safe by-products like water vapor and oxygen, ensuring safe and contamination-free transfer.

Accessories

Accessory	Description
VHP Generator	Generates and injects vaporized hydrogen peroxide into the chamber.
PLC Control Panel	Controls and automates the entire operation with programmable settings.
HMI Touchscreen	User interface for monitoring and controlling cycles.
HEPA Filter	Ensures clean and particle-free airflow inside the chamber.
Catalytic Converter	Breaks down residual H₂O₂ into water vapor and oxygen.
Pressure Sensors	Monitors chamber pressure and differential pressure.
Temperature Sensors	Tracks internal temperature for process control.
Humidity Sensors	Maintains optimal humidity for effective sterilization.
Door Interlocking System	Prevents both doors from opening simultaneously.
Inflatable Gasket	Provides airtight sealing during operation.
Data Logger	Records process parameters for validation and compliance.
SCADA/BMS Interface	Enables remote monitoring and system integration.
UV Lamp (Optional)	Provides additional surface disinfection (if required).
Pass Box Trolley (Optional)	Assists in easy material handling and transfer.

FAQs

What is a VHP Pass Box?

A VHP (Vaporized Hydrogen Peroxide) Pass Box is a cleanroom equipment used for the safe transfer of materials between controlled areas while ensuring complete surface sterilization using hydrogen peroxide vapor.

How does a VHP Pass Box work?

It operates in phases conditioning, VHP injection, dwell (exposure), and aeration. The vapor sterilizes all exposed surfaces, and then it is safely removed through an aeration system.

Where is a VHP Pass Box used?

VHP Pass Boxes are widely used in:

Pharmaceutical industries
Biotechnology labs
Sterile manufacturing areas
Research laboratories
Hospitals and healthcare facilities

What are the benefits of using a VHP Pass Box?

Effective bio-decontamination
Reduced contamination risk
Automated sterilization process
GMP and FDA compliance
Safe material transfer between cleanroom zones

What is the typical cycle time of a VHP Pass Box?

Cycle time usually ranges from 20 to 60 minutes, depending on load, chamber size, and sterilization requirements.

Is VHP sterilization safe?

Yes, VHP sterilization is safe when properly controlled. The system includes aeration and catalytic converters to break down hydrogen peroxide into water vapor and oxygen.

What materials can be sterilized in a VHP Pass Box?

Most non-porous and compatible materials such as stainless steel, glass, and certain plastics can be sterilized. Sensitive materials should be validated before use.

What is the difference between Static Pass Box and VHP Pass Box?

Static Pass Box: Used only for material transfer without sterilization
VHP Pass Box: Provides complete sterilization using hydrogen peroxide vapor

What is SAL in VHP Pass Box?

SAL (Sterility Assurance Level) indicates the effectiveness of sterilization. VHP systems typically achieve SAL of 10⁻⁶, meaning a very high level of sterility.

Accessory	Description
Pressure Gauge	Accurate pressure gauge for monitoring and maintaining optimal airflow and pressure levels.
Clean Down Timer	Timer feature for scheduling and automating the cleaning process, ensuring consistent cleanliness.
Pilot Light	Indicator light to signal the operational status of the system, providing visual feedback to users.
Buzzers	Audible alarms or buzzers to alert users of any anomalies or safety concerns, enhancing system safety.
UV Light	UV light for sterilization and improved contamination control
HMI+PLC Based Control System	To monitor and change various parameters from a single touchscreen interface which makes entire system easy to operate.
Flame Proof System (FLP)	A Complete or partial Flame Proof System along with FLP Lights to accommodate safe working environment and prevent fire hazards.

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CLEAN ROOM EQUIPMENT

Vaporized Hydrogen Peroxide Pass Box

Highlights

Highlights

Introduction

Features

Features

Working Principle

Accessories

FAQs

Related Blogs

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